Genoa handed Serie A leaders and titleholders Juventus a dramatic first league defeat of the season when Luca Antonini scored in the fourth minute of stoppage time to give them a 1-0 win on Wednesday.

The loss also ruined the day for skipper Gianluigi Buffon, who was playing his 500th match for the Italian champions.

Napoli continued on their erratic way as they threw away chances in a 1-1 draw at Atalanta where Jose Callejon fired over an open goal and Gonzalo Higuain scored a late equaliser, only to miss a stoppage time penalty.

Inter Milan, for the second successive match, won 1-0 with a controversial penalty, this time against previously unbeaten Sampdoria, as Mauro Icardi converted in the 89th minute amid angry protests from the visitors.

Mattia Destro and Daniele De Rossi gave AS Roma a 2-0 win over promoted Cesena as they pulled level with Juventus at the top. Both have 22 points from nine games, six ahead of AC Milan, Sampdoria and Udinese.

Perin, the saviour

Genoa goalkeeper Mattia Perin kept Juventus at bay, his repertoire of saves including two stops from Alvaro Morata, and Angelo Ogbonna hit the crossbar for the visitors, before Antonini scored with almost the last kick of the game.

Napoli, who beat Verona 6-2 on Sunday, found life much tougher at Atalanta and fell behind when German Denis scored with a header just before the hour. Callejon should have levelled five minutes later but managed to fire his effort over from almost underneath the crossbar.

Atalanta had Luca Cigarini sent off for a second bookable offence before Higuain scored on the turn with four minutes to go. But the Argentine turned villain when his penalty was saved by Marco Sportiello in the second minute of stoppage time, leaving his side joint sixth alongside Lazio, Inter and Genoa with 15 points.